(1) Pre-clinical Anti Nogo-A Studies & Review Papers
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Anti-Nogo-A Antibody Infusion After Stroke
Wiessner, C., et al. "Anti-Nogo-A Antibody Infusion 24 Hours after Experimental Stroke Improved Behavioral Outcome and Corticospinal Plasticity in Normotensive and Spontaneously Hypertensive Rats." Journal of Cerebral Blood Flow & Metabolism, vol. 23, 2003, pp. 154–165, doi:10.1097/01.WCB.0000040400.30600.AF.
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Intrathecal Anti-Nogo-A Treatment Improves Recovery After Stroke
Tsai, S.Y., et al. "Intrathecal Treatment with Anti-Nogo-A Antibody Improves Functional Recovery in Adult Rats after Stroke." Experimental Brain Research, vol. 182, 2007, pp. 261–266.
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Therapeutics Targeting Nogo-A Holds Promise for Stroke Restoration
Kumar, P., and L.D. Moon. "Therapeutics Targeting Nogo-A Hold Promise for Stroke Restoration." CNS Neurol Disord Drug Targets, vol. 12, 2013, pp. 200–208, doi:10.2174/1871527311312020006.
(2) Intranasal Delivery Studies & Review Publications
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Intranasal Delivery of Anti-Nogo-A Antibody
Correa D, Scheuber MI, Shan H, Weinmann OW, Baumgartner YA, Harten A, Wahl AS, Skaar KL, Schwab ME. Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2200057120. doi: 10.1073/pnas.2200057120. Epub 2023 Jan 17. PMID: 36649432; PMCID: PMC9942809.
101631,
ISSN 2352-9407,
https://doi.org/10.1016/j.apmt.2022.101631.
(https://www.sciencedirect.com/science/article/pii/S2352940722002657)
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Nasal Administration of Antibody for Alzheimer's
Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer’s disease
Juliana R. Lopes https://orcid.org/0009-0009-6136-8830, Xiaoming Zhang https://orcid.org/0000-0003-2654-3620, Julia Mayrink, +11, and Howard L. Weiner https://orcid.org/0000-0003-0203-9681 hweiner@rics.bwh.harvard.eduAuthors Info & Affiliations
Edited by Lawrence Steinman, Stanford University, Stanford, CA; received June 4, 2023; accepted July 31, 2023
September 5, 2023
120 (37) e2309221120
https://doi.org/10.1073/pnas.2309221120
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Intranasal Delivery Bypasses the Blood Brain Barrier
Hanson, L.R., Frey, W.H. Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease. BMC Neurosci 9 (Suppl 3), S5 (2008). https://doi.org/10.1186/1471-2202-9-S3-S5
(3) Stroke & Rehabilitation Facts & Figures
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Heart & Stroke Stat Update 2021
American Heart Association: https://professional.heart.org/-/media/PHD-Files-2/Science-News/2/2021-Heart-and-Stroke-Stat-Update/2021_Stat_Update_factsheet_Older_and_CVD.pdf
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The Effects of Stroke
American Stroke Association: The Effects of Stroke. Available at: www.stroke.org
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Clinical and Economic Burden of Stroke
Alqahtani F, Sengupta P, Badhwar V, et al., Clinical and economic burden of acute ischemic stroke following transcatheter aortic valve replacement. Structural Heart Journal online, 16 Nov 2018.